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In the current study, we documented the identification as well as characterization of a completely new atypical opioid receptor with special detrimental regulatory Qualities in direction of opioid peptides.1 Our final results showed that ACKR3/CXCR7, hitherto often called an atypical scavenger receptor for chemokines CXCL12 and CXCL11, is additiona
Gene expression Assessment unveiled that ACKR3 is highly expressed in numerous Mind regions comparable to significant opioid exercise facilities. In addition, its expression levels tend to be increased than People of classical opioid receptors, which further more supports the physiological relevance of its noticed in vitro opioid peptide scavenging